Stem cells enhance periodontal tissue regeneration. In recent years, bone marrow–derived mesenchymal stem cells have been the focus of research aimed at regenerating various body tissues. As an extension of this theoretical paradigm, researchers recently attempted to regenerate periodontal tissues with an animal model. The results or their experiment are published in the Journal of Periodontology (2006;77: 1003–1007). These researchers initially created osseous defects in the molars of laboratory animals. They then harvested bone marrow mesenchymal cells from the same animals and transplanted the cells into the experimental periodontal defects. Some of the osseous defects did not